PCEUT532_Midterm-2-2009_equations

PCEUT532_Midterm-2-2 - 1 1 1 1 1 1 max max 3 2 lim max C K V Cl AUC D Cl t V Cl V k Cl k k t C A C D V Cl D F C m = = = = = = = = • = max 2 1 2 1

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PHARMACEUTICS 532 Midterm#2 2009 EQUATIONS [ ] [ ] S K S V v m + = * max max * V C DR K DR m + ! = " ! + = C K V DR m 1 max C EC C E E * * 50 max = ! C EC C E E * * 50 max = td = 2.3/K (log Dose – log Amin) ( ) ( ) ! ! " # $ $ % = = = = = = = = ( = = = = ( = = = ! ! " # $ $ % = = = = ( ( = = = = = = = = = ) K e D K e D Dose Loading K e n Fluctuatio K e factor g do mulitple AUC Cl D F K V D F K V D F oral C AUC Cl D K V D K V D C Kt e ss C C Cl ss C K Q Cl e f H F Q hep Cl G F ER G F H F G F F ER IV Au oral Au F oral D IV D IV AUC oral AUC F Cl D F oral AUC Cl IV D IV AUC KT e V D F C K K Log K K T e e K K V K D F C Rate E AbsRate dt dA dt dA dt dA a a t K Kt a a E A a 1 1 1 _ 1 1 _ sin _ 0 * * * * *
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Unformatted text preview: * * * * ) 1 ( * * ) 1 ( 1 1 ) 1 ( * 1 * * max * max * 3 . 2 * * lim max C K V Cl AUC D Cl t V Cl V k Cl k k t C A C D V Cl D F C m + = = = = = = = = • = ! max 2 / 1 2 / 1 * 693 . * 693 . 2 ln / "...
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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