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Unformatted text preview: PHARMACEUTICS 532 Winter 2010
Midterm #1 January Bic Name E :2 Student # Questions Points 1 5
2 30
3. 9
4. 6 1. (5 pts) Using the frame below sketch the relationship between AUC and the dose
given. Show what is the intercept and the slope of the graph and what overall
equation describes the relationships between the two parameters. . i
A . __D_ : —,
AU... Cr , —é AUC D_ 2. (30 points) Check the appropriate answer (a through a) 2.1 The disposition of valproic acid after intravenous bolus administration is described by (\ “Ii4’"
c the equation C=Df9*e‘°'°4e‘in which time is in hours, concentration in mg/L and volume in A m Liters V = q L K: 00% 3%— ‘ a i) The halflife of valproic acid is 9 hours 4141: I1):— ; [Ll W3 _ / pub
~ M) ii) Since valproic acid is eliminated by a first—order process, the rate of elimination is ——';_ kAL constant with time i.e. the same amount of valproic acid is always eliminated in unit tim .
iii) After a 100 mg dose the concentration after 5 hours is 5.4 mglL C  o6 : ——— /r\ L
Livahe elimination rate of valproic acid after 100 mg dose at time 0 is 4.8 mgfh 6‘ __,_ S) . 93
gm 3 “4* = °~°“'3i:l00‘*5 a) i and iii are correct “ d)? 2 L' 8 h b) i, ii and iii are correct #5
iv is correct d) ii and iii are correct e) ii and iv are correct 2.2 The clearance of maraviroc is 0.01 lein/kg, its volume of distribution is 2.8 L/kg and
unbound fraction in plasma is 24% (fu=0.24). , "i ,
@ln an average subject, the halfelife of maraviroc is approximately 3 hours ' C4 ' 0‘0 I ‘7}?
@ﬁer a 4 mg/kg dose the AUC of Maraviroc is approximately 0.4 mg*minlmL A0639. x’ H” mi“
6” iv?) Zlg
iii) At plasma concentration of 1 mgi’L the free concentratggﬂaraviroc is 24 n lmL. 400%” _
’ L, I _ _ 0:023), I. Crimes
iv) When the CL of maraViroc decreases to 0.05 Limin/kg due to a drugdrug interaction ‘ the volume of distribution of maraviroc increases to 5.6 L/kg. V SRCQHW Ci Cl— and ii are correct b) i, ii and iv are correct
c) ii is correct
d) ii and iii are correct e) i and iv are correct 2.3. The ﬁgure below shows plasma concentration time curves for two drugs, drug A and B (as labeled in the graph), which are both administered as a 100 mg iv bolus. l‘] o W—__——.___MV‘!
.
. Piasina concentmtinn [mg/l.) =3 1.? 34
time (hours) i) Drug B has a higher clearance than drug A Correct loach UK MC» ii) The elimination rateconstant for drug B is greater than that of drug A ‘10 We (Ar, “:5 EV{
eq, ‘5 iii) Both drugs are cleared entirely by the liver. Hence drug A has a greater extraction ratio than drug B. @1035 , 1* > OLA EB iv) The volume of distribution of drug A is twice as high as that of drug B V (Th (‘0
A a) i and iii are correct
b) ii and iv are correct
0) i, ii and iii are correct
d i, ii and iv are correct and ii are correct 3. (9 points) in the table below fill in using arrows (Tiedhow each of the values would
change after an iv bolus administration in the situations described Clearance (CL)
increases as a
result of enzyme
inducﬁon Volume of
distribution (V)
decreases with
sepsis Dose is increased
due to therapeutic
inefficiency 1\ _l 4. (6 points) ). The table below shows values of tissuetoblood equilibrium ratios (KP)
for three different tissues for a hypothetical drug. The blood flows to the three tissues are
also shown. indicate the rank order (shortest, medium, longest) of the disrtribution half lives for the three tissues shown when distribution rate is perfusion rate—limited.
Blood flow in lemin Rank order of (perfusion rate) distribution half lives Adipose 5. (30 pts) Following an intravenous administration of 0.5 mg digoxin, the following
plasma concentration vs time parameters were obtained: Time (hours) Serum digoxin
concentration
(ng/mL) _
_ a) Prepare a semilogarithmic plot (paper provided on the next page) of the data and
determine the equation that best describes the plasma concentration profile of this drug. ?‘om graph CeAcfo‘J“ + E) {7%
L ~— 0 . 03% t 4—2240,
coma. in rig/M K ~(3‘0L2,_§‘nl\% b) Calculate the volume of the central compartment. *— r—a :: “’—  ,— ‘06) all)
Vc/ Q0 A4433 5.9+ and? 3 “1 $01” :cost. \l V_L,
. “LP— C = Cog—kI
lnC = lnCO — kt 1n2 Vln2 a” k CL =AUC EQUATIONS ...
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 Spring '08
 Storm,D
 Pharmacology, Intravenous therapy, Valproic acid, plasma concentration

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