Phcol_402_Cardiovascular_Drug_Tables

Phcol_402_Cardiovascular_Drug_Tables - Drug type Thiazides...

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Drug type Thiazides Loop Diuretics K+ sparing Diuretics Osmotic Diuretics Carbonic Anhydrase Inhibitors Examples Chlorothiazide Hydrochlorothiazide Metolazone Chlorthalidone Furosemide Torsemide Bumetanide Ethacrynic Acid Spironolactone Amiloride Triamterene Glycerol Mannitol Urea Acetazolamide Dorzolamide Mechanism of Action Inhibit Na+lCl- transporter Inhibit Na+lK+I2Cl- symporter - Aldosterone antagonist - Na+ channel blocker t osmotic pressure of plasma 3 draws water into circulation Prevents formation of HC03- (end result: less H+ excreted into lunlen) Target Location Distal tubule Ascending limb of Loop of Henle Epithelial of late distal tubulelcollecting duct Whole nephron Proximal convoluted tubule Diseases Treated Hypertension CHFIedema Diabetes insipidus Pulmonary edema CHF Hypertension Hypokalemia (induced by LDs and thiazides) Cerebral edema Acute glaucoma Acute renal failure Hypertensioil Glaucoma Mountain sich~ess Acidic urine Side Effects Hypokalemia t blood glucose, uric acid, lipids Electrolyte imbalance (hypo- K+lCa2+lMg2+. . .) Tinnitus Hypakalemia Excessive plasma volume Pulmonary edema CNS effects Hypokalemia Hyperglycemia
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Drug Type Thiazide Diuretics ACE inhibitors AT antagonists Adreuergic antagonists Examples Chlorothiazide Hydrochlorothiazide Metolazone Chlorthalidone Captopril Lisinopril Enalaprilat Enalapril Fosinopril. . . Losartan Valsartan Candesartan Irbesartan &blockers nonselective propranolol nadolol timolol 1 selective metoprolol atenolol esmolol a-blockers nonselective phentolamine phenoxybenzamine dibenamine a 1 selective prazosin Mechanism of Action Lower plasma volume Inhibit angiotensin converting enzyme Direct antagonism of AT1 receptors Block sympathetic stimulation of the heart by blocking
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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Phcol_402_Cardiovascular_Drug_Tables - Drug type Thiazides...

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