Lecture_12_Feb_1_

Lecture_12_Feb_1_ - Cytosol-to-Mitochondria Transport...

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1 Cytosol-to-Mitochondria Transport Cytosol-to-Peroxisome Transport Reading Assignment For 5 th Ed: 713-719, 721-723
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2 Cytosol-to-Mitochondia Transport Structure and function of mitochondria How is a cargo protein transported into the mitochondria?
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3 Structure of Mitochondria inner membrane (in the form of deep invagination) intermembrane space outer membrane matrix Note the invagination of the inner membrane and the electron-dense materials associated with it – what does this unique structure tell you? (high surface to volume ratio and enriched (~75%) protein content)
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4 Structure of Mitochondria – a simple version
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5 ) Mitochondria are ATP- enerating Factory for Life Function of Mitochondria (1) Mitochondria are ATP generating Factory for Life locations of oxygen-dependent energy production rokaryotes : plasma membrane prokaryotes : plasma membrane plants : chloroplasts other eukaryotes : mitochondria for each glucose metabolized: 2 ATP molecules generated in the cytosol 28 ATP molecules generated in the mitochondria (2) In addition to functioning as a power house, mitochondria play a role in apoptosis, proliferation, biosynthesis, cell injury, ….
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6 Similar mechanisms are used to generate ATP in bacteria, plants, and animals Energy released from the downhill electron transport drives the uphill proton transport Energy released from the downhill proton transport drives the ATP synthesis ECG for H + H + -dependent ATP synthase electron transport e - transport H + gradient ATP coupled H + pump
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7 The electron transport chain couples electron transport to proton gradient The electron transport occurs in a series of downhill reactions, called electron transport chain. Each reaction is coupled to the uphill proton transport which contributes to the formation of a H + gradient. ectron transport chain electron transport chain e initial the initial electron donor (NADH) the final electron acceptor (O 2 to H 2 O) The requirement of O 2 as a receiver explains the oxygen-dependence
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8 H + - ATPase couples the proton gradient to ATP synthesis electron transport chain components & ATP synthase are all located on the inner membrane. remember the high protein content as well as the deep invagination of mitochondrial inner membrane?
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9 ATP Production of Mitochondria The net reaction is the oxidation of NADH to NAD + , the reduction of O 2 to H 2 O, nd the phosphorylation of ADP to ATP Therefore it is also called oxidative and the phosphorylation of ADP to ATP. Therefore it is also called oxidative phosphorylation (oxidative: NADPH to NAD+, phosphorylation: ADP to ATP)
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10 Cytosol-to-Mitochondia Transport Structure and function of mitochondria How is a cargo protein transported into the mitochondria?
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11 Two separate genetic systems to generate the mitochondrial proteins the major pathway (99%) an important question: How are proteins synthesized in e cytosol transported into the cytosol transported into mitochondria?
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This note was uploaded on 02/01/2010 for the course MCDB 103 taught by Professor Staff during the Winter '08 term at UCSB.

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Lecture_12_Feb_1_ - Cytosol-to-Mitochondria Transport...

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