Lecture_9_Jan_25_

Lecture_9_Jan_25_ - 1 How does a membrane maintain the...

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Unformatted text preview: 1 How does a membrane maintain the compartmental specificity of a cell? Major topics to be covered in MCDB103 to study the structure and function of lipids and proteins, which are two major components of a membrane How do surface proteins allow cell communication? to study transporters and channels, which are two important classes of membrane proteins involved in cell communication How does a cell create different intracellular compartments via selective targeting of lipids and proteins? study vesicular & non esicular protein/lipid targeting which are two major to study vesicular & non-vesicular protein/lipid targeting, which are two major mechanisms of protein/lipid delivery within a cell How does cytoskeleton regulate compartmental organization and cell behaviors? to study different types of cytoskeleton (actin, microtubule and intermediate filaments) and their effects on the compartmental organization and cell behavior 2 An Overview of Intracellular Transport reading assignment 78 81 695 04 178-181, 695-704 3 Major Intracellular Compartments of an Animal Cell Each compartment has its unique protein and lipid composition. 4 main functions of intracellular organelles or compartments Nucleus: containing main genome, DNA and RNA synthesis (has two membranes) Peroxisomes: oxidize toxic molecules and fatty acids Mitochondria: ATP synthesis via oxidative phosphorylation, has its own genome (has two membranes) Chloroplasts: site of photosynthesis, has its own genome (has two membranes) ER: site of lipid and membrane protein synthesis, intracellular Ca 2+ storage for signaling (cytosolic, nuclear, mitochondrial and peroximal proteins are synthesized in the cytosol) Golgi: receives membrane proteins & lipids from ER, modifies them, and rts them into endosomes lysosomes and the plasma membrane sorts them into endosomes, lysosomes, and the plasma membrane Endosomes: storage and sorting compartments of internalized plasma membrane proteins and lipids Lysosomes: degradation site for cellular organelles and macromolecules, as well as internalized foreign particles. 5...
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Lecture_9_Jan_25_ - 1 How does a membrane maintain the...

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