Chemical Sex Changes?
Male and Female Sexual Development
Endocrine Disruption
Types of Disruptors
Environmental Examples
Human Implications
Summary and Conclusions
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Some Important Definitions
Genotypic
sex – defined by the X and Y chromosomes.
Phenotypic
sex – physical expression of sexual
characteristics.
Endocrine system –
hormones
which control many
activities, including development, reproduction, and
behavior.
Xenoestrogen
– a foreign chemical with estrogenic
properties.
Xenoandrogen
– a foreign chemical with androgenic
properties.
The Steroid Hormones
Steroid hormones are naturally
synthesized from
cholesterol.
Control female and male reproduction.
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Actions of Hormones and their
Mimics
Endocrine disruption – deleterious effect of a foreign
substance that
mimics or blocks the action of the
natural hormone.
Functions of Testosterone in Males
Stimulate
spermatogenesis
in the testicles.
Stimulate development of
secondary sexual
characteristics
(muscle mass, hair growth, deep voice).
Stimulate development of
support organs
(prostate,
seminal vesicles, cowpers glands).
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- Fall '09
- RonTjeerderma
- estrogen, DDE, endocrine disruptors, endocrine disruption, Development Endocrine Disruption
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