MIC 205 - Study Guide (Test 4)

MIC 205 - Study Guide (Test 4) - Antonio Alarcon MIC 205...

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Antonio Alarcon MIC 205 Study Guide #4 11/21/07 Infectious Diseases of the Skin and Eyes Skin Structure Natural Defenses of the Skin Keratin Skin sloughing Sebum: low pH, high lipid Sweat: low pH, high salt, and Lysozyme, which digests peptidoglycan Normal Skin Flora Propionibacterium acnes Corynebacterium sp. Staphylococci Staphylococcus epidermidis Staphylococcus aureus Streptococci sp. Candida albicans (yeast) Many others The Eye Normal flora sparse Similar to skin flora
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Tears have lysozyme, IgA Bacterial Skin Infections Acne Necrotizing fasciitis Leprosy Acne Propionibacterium acnes: Gram + rod Digests sebum Attracts neutrophils Neutrophil digestive enzymes cause lesions, “pus pockets” Acne Most common skin disease in humans     Oil-based cosmetics worsen disease No effects of diet Acne Treatments Benzoyl peroxide dries plugged follicles, kills microbes     Tetracycline (antibiotic)     Accutane – inhibits sebum formation     Necrotizing Fasciitis  “Flesh Eating Strep” Streptococcus pyogenes (Group A Strep) Tissue digesting enzymes Hyaluronidase Streptokinase Streptolysins Rapidly spreading cellulitis may lead to loss of limb     Necrotizing Fasciitis Disease starts as localized infection Pain in area, flu-like symptoms Invasive and spreading May lead to toxic shock      (drop in blood pressure) Incidence 1-20/100,000 30-70% mortality Surgical removal, antibiotics Hansen’s Disease: Leprosy Mycobacterium leprae Disease of skin and nerves Change of pigmentation, loss of sensation  Slow progressing Transmits poorly Droplet or skin contact? Hansen’s Disease: Leprosy Mycobacterium leprae Acid fast bacterium     Slow growth Strict parasite Multiplies in macrophages     Prefers cool areas of body     
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Long course, drug cocktail     Virus Infections of the Skin: Rashes Maculo-papular rashes (flat to slightly raised colored bump) Measles virus  (Rubeola) Rubella virus   (German Measles) Roseola  (Human Herpesvirus-6) Fifth Disease (Human Parvovirus B19) Measles Viral infection through aerosol droplet: One of the MOST communicable viruses  Initial infection of the oro-pharynx     local infection lymph node(s) (of the neck)  lymphocyte associated viremia o Fever, malaise Spread throughout the body  Shed in respiratory tract secretions  o Koplik’s spots o Skin Rash Recovery; life long immunity Effective childhood vaccine (2-3 doses): MMR (measles, mumps, rubella), but disease still 
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MIC 205 - Study Guide (Test 4) - Antonio Alarcon MIC 205...

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