This preview shows page 1. Sign up to view the full content.
Unformatted text preview: s 171: 97-107. Mensink & Katan (1990) New Engl. J. Med. 323: 439-445. Mozaffarian (2006) Atherosclere. Suppl. 7: 29-32. Mitchell et al. (2005) Biochim. Biophys. Acta 1734: 269-276. 8. A. w-3 fatty acids are fatty acids that have a cis double bond between the 3rd and 4th carbons from the methyl end. Examples are a-linolenic acid (C18:3) and docosahexaenoic acid (DHA, C22:6):
O a-linolenic acid
HO O HO DHA Humans cannot synthesize these fatty acids de novo and must obtain them from the diet. We can, however, convert a-linolenic acid into other w-3 fatty acids. A rich dietary source is fish that live in cold water, such as salmon, herring and mackerel. Such fish obtain polyunsaturated fatty acids from algae that contribute to their diet. B. w-6 fatty acids, which contain a double bond between the 6th and 7th carbons from the methyl end, are converted into prostaglandins that can act as inflammatory agents. They also are converted to thromboxanes, which can cause platelets to clump, leading to thrombosis. w-3 fatty acids also give rise to these compounds, but at lower rates, and they also lead to formation of antiinflama...
View Full Document
This note was uploaded on 02/02/2010 for the course BIOCHEMIST Biochem 44 taught by Professor Parson,young during the Winter '10 term at University of Washington.
- Winter '10