Lecture 3 Questions - Lecture 3 1 Below the Tm cholesterol...

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Lecture 3: 1) Below the Tm, cholesterol makes membranes more/less fluid because… 2) Lipid rafts have a higher/lower concentration of cholesterol than the rest of the membrane? 3) Draw the structures of isoprene, isopentyl pyrophosphate, and dimethylallyl pyrophosphate 4) a. Why are two molecules of NADPH required in order to convert HMG-CoA to mevalonate? b. Draw the structures of the metabolite reactants and products of HMG-CoA reductase. 5) The third phosphate added to mevalonate during its conversion to isopentylpyrophosphate is lost immediately as inorganic phosphate. How were scientists able to tell that this phosphate actually gets attached to the mevalonate molecule before being lost?
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6) One of the main reactions that occurs during the synthesis of cholesterol from squalene involves ______________ acting as nucleophiles and attacking ______________ ions. 7) How many carbons does each of these molecules have? Isoprene __ Geranyl-pyrophosphate __ Mevalonate __ Farnesyl-pyrophosphate __ HMG-CoA __ Squalene __ Lanosterol __ Cholesterol __ 8) a) True/False. Cholesterol is an allosteric inhibitor of HMG-CoA reductase
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