Lecture 8 Questions - sequence, using structures , of the...

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Lecture 8: 1) How do hepatocytes generate ammonia? Is the ammonia released free in the blood stream? 2) What intermediate links the urea cycle and the citric acid cycle? How does this partially offset the energetic cost of the urea cycle? 3) Write the reaction catylzed by carbamoyl phosphate synthetase I. Why does this reaction require two molecules of ATP? Where does this reaction occur? 4) List two ways in which the urea cycle is regulated. 5) The urea cycle consumes aspartate and generates fumarate. Draw the reaction
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Unformatted text preview: sequence, using structures , of the conversion of fumarate back to aspartate. 8) Why would a defective Asp/Glu exchanger impair the urea cycle? 9) Lecture 8 mentioned three exchangers in the mitochondrial membrane. For each one, name the molecules that are exchanged and indicate whether the molecule is transported to the mitochondria or the cytosol. 10) Why does treatment with benzoate or phenyllactate help patients who have genetic disorders in urea cycle enzymes?...
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Lecture 8 Questions - sequence, using structures , of the...

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