Lecture 8 Questions KEY - Lecture 8: 1) How do hepatocytes...

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Lecture 8: 1) How do hepatocytes generate ammonia? Is the ammonia released free in the blood stream? From breakdown of amino acids to alpha-keto acids (which are then fed into the  citric acid cycle). Ammonia is NOT released into the blood stream. It is  transferred through the body as Gln. 2) What intermediate links the urea cycle and the citric acid cycle? How does this partially offset the energetic cost of the urea cycle? Fumarate – conversion of fumarate to oxaloacetate by malate dehydrogenase  produces NADH. 3) Write the reaction catylzed by carbamoyl phosphate synthetase I. Why does this reaction require two molecules of ATP? Where does this reaction occur? Bicarbonate + ATP   carbonic-phosphoric acid anhydride + ADP Carbonic-phosphoric acid anhydride + ammonia   carbamate + Pi Carbamate + ATP   carbamoyl phosphate + ADP 4) List two ways in which the urea cycle is regulated. Carbamoyl phosphate synthetase I is allosterically activated by N-
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Lecture 8 Questions KEY - Lecture 8: 1) How do hepatocytes...

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