Worksheet Thermodynamics of glycolysis_KEY

Worksheet Thermodynamics of glycolysis_KEY - Worksheet #6:...

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Worksheet #6: Thermodynamics of Glycolysis Consider reaction A below: Glyceraldehyde 3-phosphate + P i + NAD + 1,3-Bisphosphoglycerate + NADH + H + ∆G’ 0 ≈ 5kJ/mole a) Draw the structures for Glyceraldehyde 3-phosphate (G3P) and 1,3-Bisphosphoglycerate (1,3-BPG). For the structures, please see p. 529. b) Is this an Oxidation, Reduction or both? Why? Oxidation number for G3P is 0, Oxidation number for G3P is +2 therefore G3P is being oxidized. In order for one compound to be oxidized another one has to be reduced: In this case: NAD + is reduced to NADH. c) Which step of glycolysis is it? What is the name of the enzyme that catalyzes this reaction? 6; Glyceraldehyde 3-phosphate dehydrogenase. d) Is this reaction endergonic or exergonic under standard conditions? Why ? Endergonic as ∆G’ 0 is positive. e) In the cytosol we have the following concentrations: [G3P] = 3μM; [NAD + ] = 5mM; [NADH] = 1mM; [P i ] = 15mM. In order for this reaction to occur in the cell what would [1,3BPG] have to be? Note: Make sure to always convert to M for all of your calculations in thermodynamics.
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Worksheet Thermodynamics of glycolysis_KEY - Worksheet #6:...

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