glycolysis worksheet_solutions

glycolysis worksheet_solutions - 8 Phosphoglycerate mutase...

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enzyme General function Step # Glycolytic enzyme Reaction Byproducts (e.g. ATP →ADP) Oxidation ? Reversible? kinase Phosphoryl group transfer 1 hexokinase Glucose → G -6-P ATP → ADP no no isomerase Rearrangement of molecule (same molecular formula, but different structure) 2 phosphohexoisomerase G-6-P F-6-P ___ no yes 3 Phosphofructokinase-1 F-6- P →F -1,6-bisP ATP → ADP no no aldolase Aldol reaction (addition of ketone to aldehyde) 4 aldolase F-1,6-bisP G-3P + DHAP ___ no yes 5 Triose phosphate isomerase DHAP G-3-P ___ no yes dehydrogenas e Oxidation/reduction by hydride transfer 6 Glyceraldehyde phosphate dehydrogenase G-3-P 1,3-bisP- Glycerate P i + NAD + NADH + H + yes yes 7 Phosphoglycerate kinase 1,3-bis-P glycerate 3-phospoglycerate ADP → AT P no yes mutase shifts functional groups within one molecule
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Unformatted text preview: 8 Phosphoglycerate mutase 3-phosph-G ↔ 2-phospho-G ____ no yes 9 enolase 2-phospho-G ↔ PEP -H 2 O no yes 10 Pyruvate kinase PEP → pyruvate ADP → ATP no no 1) Write the Net equation for glycolysis. Glucose + 2NAD + + 2ADP + 2P i → 2 pyruvate + 2NADH + 2H + + 2ATP + 2H 2 O 2) Which reactions (steps) are shared with gluconeogenesis? 2,4,5,6,7,8,9 3) How can we generate PEP from Pyruvate. Draw a the reaction . (Lehninger 5.ed, pg. 554) 4) What happens to pyruvate under anaerobic conditions in muscle cells? What are the products? Reduction of pyruvate to lactate, regenerating NAD + from NADH + H + . 5) Why is this important? regenerating NAD + , which is important for Glycolysis especially in muscle tissue since that ’ s the only ATP-source, without NAD + glycolysis would not be able to run...
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glycolysis worksheet_solutions - 8 Phosphoglycerate mutase...

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