This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: conformation of adjacent subunits > favoring R-state CO 2 = binds at N-terminus of each subunit > favors T state by release of H + and stabilization through ionic interactions (with positively charged residue, e.g. ARG) H + = protonates HC3, favoring the T-state 2,3 BPG = binds to center of hemoglobin molecule through interactions with positively charged residues that surround pocket in T-state 6) How does each effector effect the O 2 affinity of hemoglobin? O 2 = increase CO 2 , H + , 2,3 BPG = decrease NOTE: Carbon Monoxide also acts as a modulator. Where does it bind and how does that effect the O 2 affinity of hemoglobin? Since carbon monoxide binds to the heme-group (just like oxygen) is increases the affinity for oxygen and therefore inhibits the release of oxygen in the tissues (where it can cause hypoxia)....
View Full Document
- Winter '09
- Hemoglobin, Carbon monoxide, O2 affinity