BIO 328 Resistance to Blood Flow and Fluid Exchange Blackboard 2009

BIO 328 Resistance to Blood Flow and Fluid Exchange Blackboard 2009

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Unformatted text preview: 1 MAP = CO x R, where MAP = mean arterial blood pressure CO = cardiac output R = total peripheral resistance MEAN ARTERIAL PRESSURE ( MAP ) ACROSS THE SYSTEMIC CIRCULATION = MAP (aorta) Mean Central Venous Pressure (SVC, IVC junction) = MAP (aorta) ( 0) 2 Fig. 12.31a MAP = 0.33 PP + DP Fig. 12.30 3 Fig. 12.31b Effects of Age on MAP The Vascular System 4 Relationships Between Pressure, Flow and Resistance: Poiseuilles Law P = Flow x Resistance (to flow) or Flow = P / Resistance (to flow) Flow is directly proportional to the HYDROSTATIC pressure gradient Flow P 5 6 Resistance Opposes Flow Flow = P / Resistance Flow 1 / R (Flow is inversely proportional to resistance) R = resistance R = ( 8 L ) / ( r 4 ) L = length of tube = viscosity of fluid r = radius of tube Flow ( r 4 ) / ( 8 L ) P 7 P = FLOW x Resistance Across the entire cardiovascular system P = Mean Arterial Pressure Flow = Cardiac Output Resistance arteriolar radius, length, hematocrit MAP = CO X RESISTANCE MAP = CO x R, where MAP = mean arterial blood pressure CO = cardiac output R = peripheral resistance 8 Arterioles play 2 major roles: (1) Determine the relative distribution of blood flow to individual organs, (2) Determine resistance to blood flow across the entire CVS For individual organs: FLOW = P / R P = Blood Pressure Gradient Across an Organ Fig. 12.33 Total Blood Flow is Constant P is Constant Effects of Changes in Arteriolar Radius on the Relative Distribution of Blood Flow Flow = P / R 9 Fig. 12.33 Total Blood Flow is Constant but Flow to Organ 3 Differs P is Constant Effects of Changes in Arteriolar Radius on the...
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This note was uploaded on 02/02/2010 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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BIO 328 Resistance to Blood Flow and Fluid Exchange Blackboard 2009

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