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BIO 328 Regulation of Respiration Blackboard 2009

BIO 328 Regulation of Respiration Blackboard 2009 -...

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1 Regulation of Respiration NEURAL CONTROL OF RESPIRATION Voluntary and involuntary control Respiratory rate and depth of ventilation are NOT fixed.
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2
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3 Hering-Breuer Reflex SENSORY RECEPTORS Peripheral Chemoreceptors Central Chemoreceptors
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4 Activated by Arterial P O 2 (hypoxia) Or by Arterial H + (metabolic acidosis) Or by Arterial P CO 2 (respiratory acidosis) Driving force: P O 2 NOT O 2 content
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5 P CO 2 held constant @ 40 mmHg
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6 Don’t forget: Partial Pressure Blood Content Carbon Monoxide Poisoning Very small changes generate very large effects in ventilation In large measure a response to H + : 70% Central 30% Peripheral CO 2 + H 2 O H 2 CO 3 H + + HCO 3 -
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7 SENSORY RECEPTORS Peripheral Chemoreceptors Central Chemoreceptors
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8 Respiratory Acidosis
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9 Metabolic Acidosis EFFECTS OF pH ( H + ) SEPARATE FROM CHANGES IN Pco 2
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10 Effects of ‘Recreational Hyperventilation’ X X Loss of consciousness Chemoreceptor stimulation of ventilation interActive PHYSIOLOGY: RESPIRATORY SYSTEM, CONTROL OF RESPIRATION, HYPOVENTILATION, p 12
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BIO 328 Regulation of Respiration Blackboard 2009 -...

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