BIO188_Outline_Nov4

BIO188_Outline_Nov4 - BIO 188 November 4, 2009 BIO 188...

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Unformatted text preview: BIO 188 November 4, 2009 BIO 188 November 4, 2009 For exam Monday 1. bring ASU I D card 2. dont need to memorize Nernst equation, but need to know what it means and how to use it 1. can bring calculator for comfort, but probably wont need it Today: 3. resting membrane potential 1. generating and understanding Vm rest 2. equilibrium potential for K + 4. Nernst equation 5. excitable cells (begin action potential) How do we generate a resting membrane potential? How do we generate a resting membrane potential? 6. Resting Vm is electrical potential across plasma membrane of cell that is not excited (no rapid Vm) 7. Involves 2 factors: 1. 1) .. permeability of plasma membrane to k + 1. membranes of resting cells are permeable to K + 2. K + efflux via passive K efflux via passive K + leak channels is most important contributor to resting Vm leak channels is most important contributor to resting Vm 3. Na + flux also contributes But why does K+ move out of cell, leaving negative charge on inside of plasma membrane? But why does K+ move out of cell, leaving negative charge on inside of plasma membrane? Whats other factor is required to generate and maintain ( ) resting Vm? Whats other factor is required to generate and maintain ( ) resting Vm? 8. .. ; Large chemical gradient for k+ and (and NA+) across plasma membrane. 1. [K + ] much higher inside cell than outside cell 2. [K + ] in = 150 mM; [K + ] out = 5 mM 3. given the chance, K + diffuses down [gradient] What generates K+ concentration gradient? What generates K+ concentration gradient?...
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BIO188_Outline_Nov4 - BIO 188 November 4, 2009 BIO 188...

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