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Unformatted text preview: BIO 188 November 6, 2009 BIO 188 November 6, 2009 • Nernst simulator link • You are responsible for everything in Wed outline even though we won’t go through everything in lecture • Details of chemical synapse will be on Final Exam, not Exam 3 • Today: 1. a few questions about membrane potential 2. generation of action potential 3. propagation of action potential 4. time for questions? Clicker: 5. Polrized 6. All of the above 7. Hyperbolized is more negative charge… Neurons and muscle cells are excitable! What does that mean? • .. Are subject to transient changes in membrane permeability ( Are subject to transient changes in membrane permeability ( ∴ Vm) and can fire ∆ Vm) and can fire ∆ action potentials action potentials What does a cell need in order to be “excitable?” • ...” gated” ion channels 1. excitable cells have ligand-gated ion channels ligand-gated ion channels to respond to signal from another cell 2. cell membrane needs voltage-gated voltage-gated ion channels ion channels to fire action potentials Neuronal signaling based on r apid changes in Vm Neuronal signaling based on r apid changes in Vm...
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- Spring '08
- voltage-gated k+ channels