BIO188_Outline_Oct30

BIO188_Outline_Oct30 - BIO 188 October 30, 2009 BIO 188...

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Unformatted text preview: BIO 188 October 30, 2009 BIO 188 October 30, 2009 Exam info Today: 1. Continue signal transduction 2. G protein-coupled receptors that regulate cAMP production 3. steroid hormone signaling Rule of thumb: Rule of thumb: 4. Each receptor binds only one type of signaling molecule but . 5. Signaling molecules bind to more than one receptor subtype 1. example: epinephrine binds to and adrenergic receptors in different cell types 6. Why do you suppose that is? Why do you suppose that is? 7. We used many types of recopter.. We used many types of recopter.. Again, how do most peptide and hydrophilic hormones elicit responses in target cells? 1. .. .Most bind to G protein-coupled receptors that regulate 2 nd messengers 1. examples of 2 nd messengers: cyclic AMP (cAMP), I P 3 , diacylglycerol, Ca 2+ 8. What is the 1 st messenger? H a rmon 1. 2 nd messengers change fx of specific cellular proteins 9. End result almost always ?? 10. .. What steps are involved in transducing cell-surface signal to intracellular 2 nd messenger? 11. 1- Hormone binds to and activates receptor (change conformation) 12. 2- R* activates a transduction molecule: G protein G protein 13. G protein* transduces signal to cell interior 14. 3- G protein* binds to and changes activity of effector molecule 15. an enzyme that produces 2 nd messenger Where does G protein get its name? 16. =GTP-binding protein 17. G proteins belong to the larger group of enzymes called GTPases 18. GTP (guanosine t riphosphate) is in cells 19. Contain , and subunits 20. Activation of G protein involves: 1. release of GDP and binding of GTP...
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This note was uploaded on 02/02/2010 for the course BIO 188 taught by Professor Capco during the Spring '08 term at ASU.

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BIO188_Outline_Oct30 - BIO 188 October 30, 2009 BIO 188...

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