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BIO188_Outline_Oct30

BIO188_Outline_Oct30 - B IO 188 Exam info Today 1 Continue...

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BIO 188 October 30, 2009 BIO 188 October 30, 2009 Exam info Today: 1. Continue signal transduction 2. G protein-coupled receptors that regulate cAMP production 3. steroid hormone signaling Rule of thumb: Rule of thumb: 4. Each receptor binds only one type of signaling molecule but …. 5. Signaling molecules bind to more than one receptor subtype 1. example: epinephrine binds to α and β adrenergic receptors in different cell types 6. Why do you suppose that is? Why do you suppose that is? 7. We used many types of recopter..
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Again, how do most peptide and hydrophilic hormones elicit responses in target cells? 1. .. .Most bind to G protein-coupled receptors that regulate 2 nd messengers 1. examples of 2 nd messengers: cyclic AMP (cAMP), IP 3 , diacylglycerol, Ca 2+ 8. What is the 1 st messenger? Harmon 1. 2 nd messengers change fx of specific cellular proteins 9. End result almost always ?? 10. .. Δ What steps are involved in transducing cell-surface signal to intracellular 2 nd messenger? 11. 1- Hormone binds to and activates receptor (change conformation) 12. 2- R* activates a transduction molecule: G protein 13. G protein* transduces signal to cell interior 14. 3- G protein* binds to and changes activity of effector molecule 15. an enzyme that produces 2 nd messenger
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Where does G protein get its name? 16. … =GTP-binding protein 17. G proteins belong to the larger group of enzymes called GTPases 18. GTP (guanosine triphosphate) is in cells 19. Contain α , β and γ subunits 20. Activation of G protein involves: 1. release of GDP and binding of GTP 2. dissociation of α subunit from β and γ 3. GTP-bound α
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