Lecture 4 08 - NERVOUS SYSTEM 3 Chapter 13 and 5 pages of...

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1 NERVOUS SYSTEM 3 Dr. Phelps Chapter 13 and 5 pages of Chapter 19 (see below) Lecture 4 I. Blood supply of the CNS and relevance to cortical function II. Telencephalon: Basal ganglia and the basal forebrain nuclei III. Diencephalon: Thalamus and hypothalamus I. Blood supply of the CNS -Arteries on p 566-567 and Veins/sinuses on p 577-578 A. CNS is protected by the blood brain barrier (p 560-561) 1. Special features of endothelial cells in the brain contribute to the blood brain barrier: a. Endothelial cells in the brain are NOT fenestrated, i.e. do not have pores. b. Endothelial cells in the brain have tight junctions between them. Molecules selectively transported into the brain. c. Capillaries covered with astrocytic endfeet B. Two major arteries supply blood to the brain 1. Internal carotid and vertebral/basilar arteries 2. Three major cerebral arteries : Fig. 19.10 anterior cerebral artery middle cerebral artery posterior cerebral artery
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2 3. Note that the anterior and posterior communicating arteries form the Circle of Willis . 4. Strokes: Circulatory problems in the CNS cause loss of cortical function (see Fig. 13.23): a. Block of middle cerebral artery: hemiplegia b. Block of posterior cerebral artery C. Unusual venous drainage of brain- Fig. 19.20 1. Venous blood and CSF leave the brain by dural sinuses
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This note was uploaded on 02/03/2010 for the course NEUROSCI 101A taught by Professor Scheibell during the Winter '10 term at UCLA.

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Lecture 4 08 - NERVOUS SYSTEM 3 Chapter 13 and 5 pages of...

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