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TriglycerideHydrolysisKey - adenylate cyclase 1 HSL(less...

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a. Kinesiology 200 Lab Computer Lab - Triglyceride Hydrolysis (10 points) KEY Draw thethree steps of triglyceride (TG) hydrolysis, including enzyme names. Highlight the enzymes in yellow. triglyceride + HzO ---+ digtyceride + FA TG lipase (or HSL) diglyceride + HzO --+ motloglyceride + FA TG lipase (or HSL) monoglyceride + HzO -, glycerol + FA MG lipase Following TG hydrolysis inthe adipose tissue, glycerol is released into the blood. Where does it go from there? liver Following TG hydrolysis in the adipose tissue, where do the fattyacids (FA) go? Mitochondria (in AT or other tissue like heart, muscle, or liver) What are the FA's (from question #3) used for? ATP production via beta oxidation & Krebs cycle (can also be used for TG synthesis in the liver) Draw a representation of the covalent modification of HSL. Highlight the enzymes in yellow. (HSL is also sometimes referred to as TG lipase.)
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Unformatted text preview: adenylate cyclase 1. HSL (less active HSL-P (active) .--TG--*FA's---+glycerol 2. 4. 6 CAMP r**v PK.A PKA-P (less active (active) or inactive {"-a*.-"^ " "-'-**"'-&*q*,*"--. ... t/n phosphodiesterqse--+ r )) 5'adenylate ,E ottn"gr,ul) ._,*. __*.--a protein phosphatase 6. Fill-in the followino table. Effect on TG Hydrolysis Detailed Mechanism Catecholamines (via cr2 receptor) INC DEC Inhibit adenylate cyclase.--- IcAMP---+ JPKA (active)--- JHSL-P Catecholamines (via B1 receptor) INC / DEC Stimulate adenylate cyclase.--- fcAMP --+ lPKA (active)--- tHSL-P Insulin INC / DEC Mechanism #1 f phosphodiesterase---+ JcAMP --- J PKA (active) -' JHSL-P Mechanism #2 Jprotein phosphatase---) t HSL (not phosphorylated, therefore less active) Exercise INC / DEC J catecholamines (via p1 receptor) J insulin Fasting INC / DEC J insulin Fed INC / DEC f insulin...
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