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4pp_3.Cholesterol - Cholesterol makes phospholipid...

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12/29/2009 1 3. Cholesterol & lipoproteins Cholesterol makes phospholipid membranes more plastic with HO cholesterol Temperature cholesterol without cholesterol Cholesterol associates with sphingolipids and certain proteins to form “rafts” in the plasma membrane lipid raft protein with glycosyl- phosphatidylinositol (GPI) anchor at carboxyl end sphingolipids & other phospholipids other Lipids probably are more ordered in rafts than elsewhere in the membrane because sphingolipids usually have long, saturated fatty acid side chains cholesterol phospholipids Cholesterol serves as a precursor for steroid hormones & bile acids HO O O OH cholesterol progesterone HO O O CH 2 OH O OH testosterone estradiol cortisone cholate CO 2 - HO OH OH O
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