Final - ECEN 689 - Statistical Computation in Genomic...

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ECEN 689 - Statistical Computation in Genomic Signal Processing Final Exam – Fall 2009 Exam Policy : The exam is closed-book, closed-notes. Please do not use calculators and turn off your cell-phones, I-pods, etc. To make accurate grading possible, please write your solutions cleanly and concisely. Any questions you have about the exam should be possible to ask publicly. Please initial all the pages of your solutions. Problem 1. (30 points) A compound produces the following mass spectrum (where peaks with height smaller than 0.1 were discarded): Given that the compound contains only C, H, and O, find the formula of the compound. Recall that C is a X+1 element and O is a X+2 element, with isotopic ratios 1:0.0108 and 1:0.00205, repectively. Use the approximation 45 × 0 . 0108 2 = 5 . 2 × 10 - 3 . Problem 2. (20 points) This problem concerns hypothesis testing. Assume that the analysis starts with 1000 genes, only 100 of which are in truth differentially-expressed. (a) Application of a test to each gene outputs a list of 144 genes. Later validation establishes
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Final - ECEN 689 - Statistical Computation in Genomic...

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