This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: ECEN 689 - Statistical Computation in Genomic Signal Processing Fall 2009 Homework 1 Due on: October 1, at the start of class. Homework Policy : You are expected to write cleanly and concisely, and demonstrate that you understood the problem and its solution. You can discuss the problems with your colleagues if you wish but each student must write their own solutions separately. Late homework cannot be accepted, unless there is a documented valid reason. Please sign and staple your homework. Problems: 1. Cystic fibrosis is caused by a mutation in the gene that codes for cystic fibro- sis transmembrane conductance regulator (CFTR), a complex protein that sits across the cell outer membrane and acts as a pump to move chloride to and from the cell cytoplasm. The gene is located in the long arm of chromosome 7 (see figure). A mutation in this gene produces a dysfunctional protein, which leads to an imbalance in the concentration of salt and water in the surroundings of certain cells, leading to the production of thick mucus that obstructs narrow passages in some organs. (a) Obtain the first few bases (sense) that make up the ORF of the CFTR gene. From this, give the first few aminoacids that are coded in this gene. Hint: You will search the information stored at the National Center for Biotechnology Information (NCBI). Enter the NCBI site at: http : // www...
View Full Document
- Spring '10
- Signal Processing