The halflife of a drug is 4 hours and its volume of distribution in a patient is
45 L.
(A) What infusion rate is required to maintain a concentration of 20 mg/L in
this patient?
(B) What is the clearance of this drug?
(C) What loading dose would you have to give this patient to bring him to 20
mg/L?
(D) If you stopped infusing drug into this patient and he had a drug
concentration of 20 mg/L at that time, how much time would elapse until
his body concentration was 3.5 mg/L?
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View Full DocumentIn accordance with the plateau principle, if the halflife of a drug is 4 hours,
how many hours will it take to reach 75% of the steady state concentration.
A dose of 200 mg of drug X was rapidly given intravenously to your patient
(assume instantaneous distribution throughout this drug’s volume of
distribution).
Six hours later the concentration of drug X in his plasma was 10
mg/L.
The drug has a halflife of four hours.
What is the volume of distribution
of drug X in your patient?
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 Spring '08
 SISSON
 Pharmacology, bmax

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