Dose-response relationships
A central question of drug therapy is: “What is the proper dose of a drug
that will produce the desired therapeutic effect without harmful side
effects”.
Relationships between
doses and responses are
discussed in terms of
log
(dose) - responses (or
LDR
)
curves.
There are threshold
doses for action, as well as
maximally-effective doses.
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Properties of Log (dose) - Response Curves
1.
These curves describe the LDR
relationship over a wide range of
doses.
2.
LDR curves are typically
sigmoidal (“S” shaped).
The
middle section is approximately
straight, facilitating statistical
analyses.
3.
The same effect is produced by
different drugs that act by
identical or at least similar
mechanisms.
Dose-response relationships
allow one to quantitatively
compare drugs.
Question: How do
the potencies of
drugs A and B
compare?
Linear
Log
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Interpreting LDR curves: receptor occupancy
Drugs must attach to their sites of action (receptors) in the body in
order to exert their actions.
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- Spring '08
- SISSON
- Pharmacology, TI, LDR curves, toxicity LDR curves, efficacy LDR curves
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