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Lecture-07 Pharmacokinetics II

Lecture-07 Pharmacokinetics II - Effect of dosing on...

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Effect of dosing on duration of drug action can be dramatic if absorption is not fast in comparison with elimination. At low doses the drug effect appears quite late and lasts only a short time. Larger doses bring about an earlier appearance of the drug effect, and last substantially longer.
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Repeated drug administrations The goal of therapeutics is to maintain the drug concentration above the threshold level for effectiveness ( C ther ) and below the toxic concentration ( C tox ). This can be accomplished by multiple dosing strategies. An initial loading (or priming) dose can be used to more rapidly achieve C ther , with maintenance doses given at regular maintenance intervals
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Bioavailability: The percentage of a drug that enters the systemic circulation in an unchanged form after administration. Bioequivalence: Comparable bioavailability between related drugs. Therapeutic equivalence: Comparable clinical effectiveness and safety between similar drugs. Some definitions
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Measurements of bioavailability 2. Plasma concentration measurements: after a single oral dose of drug, serial plasma measurements are made,
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