Electron Transport and Oxidative Phosphorylation

Electron Transport and Oxidative Phosphorylation - Electron...

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Unformatted text preview: Electron T ransport and Oxidative Phosphorylation NADH and FADH 2 made by the TCA cycle are readily reoxidized ETC and oxidative phosphorylation are systems to conserve the energy of e- transfer as chemical energy in the form of ATP ETP is located in the cytoplasmic membrane of bacteria and in the inner membrane of eukaryotic mitochondria enzymes of TCA cycle are located in the matrix, except SDH, which is in the inner membrane Proteins & coenzymes of the ETC are in the inner membrane Mitochondrion has its own genome and ribosomes, but most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondrion Electrochemistry o = standard reduction potential = quantitative measure of the easue with which a chemical species is reduced G = -nF = electron acceptor couple - electron donor couple o std. red. pot. is measured in a rxn -cell measured under std. conditions: reactants are at 1 M and H 2 is at 1 atm (pH ref. cell = 0) sample -cell has 1M of solutions of reduced and oxidized forms of species being measured reference -cell contains 1M H + /H 2 at 1 atm arbitrarily assigned std. red. pot. of 0 V if e- flowed from sample to reference, std. red. potential <0 b/c reduction is occurring at reference cell > 0: compound on left of rxn is good oxidizing agent < 0: compound on right of rxn is good reducing agent rxn w/more negative red. pot. dontates e- to rxn w/ more positive red. pot. -cell rxns describe rxns in cells; always written in direction of reduction in biochemistry, pH=7 thus, we need an reduction potentials are more positive than at pH 0 t rue physiological potential also depends on [reactants] and [products] ETC o overview In E. Coli,e- s pass from NADH from ubiquinone (which is reduced to ubiquinol) to oxygen (which is reduced to water) using Complexes I and IV in mitochondria, the ETC comprises of 4 large protein complexes in the inner membrane, a mobile e- carrier in the membrane (ubiquinone), and a soluble protein e- carrier in the inter-membrane space (cytochrome c) complex I I is succinate dehydrogenase from the TCA cycle e- s from NADH pass through complexes I and I I I, and then...
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This note was uploaded on 02/09/2010 for the course BIOL 3361 taught by Professor Zhang/spiro during the Fall '08 term at Dallas.

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Electron Transport and Oxidative Phosphorylation - Electron...

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