Chapter 12

Chapter 12 - Chapter 12 Gene Control of Enzyme Structure o Garrod's Hypothesis of Inborn Errors of Metabolism(1902 alkaptonuria biochemical

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Chapter 12 Gene Control of Enzyme Structure o Garrod’s Hypothesis of Inborn Errors of Metabolism (1902) - alkaptonuria biochemical disorder caused by mutation in a gene encoding an enzyme in a particular metabolic pathway work provided 1 st evidence of a specific relationship btwn genes & enzymes position of block in metab. pthwy can be dtrmned by accmlation of chem. comp. o showed that genes act by regulating definite chemical events Isolation of Nutritional Mutants of Neurospora wt protorophic Neurospora only needed a smiple minimal medium o reasoned that it synth other materials it needed for grwth from chemical present in minimal medium o should be able to isolate auxotrophs that required nutritional supplements to grow x-ray X mutants w/ wt of opposite mating type (ensuring any zuxotrophic mutant isolated had genetic basis for requiring nutrient) 1 spore/eascus allowed to germinate in a
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This note was uploaded on 02/09/2010 for the course BIOL 3301 taught by Professor Hannig/miller during the Spring '10 term at Dallas.

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Chapter 12 - Chapter 12 Gene Control of Enzyme Structure o Garrod's Hypothesis of Inborn Errors of Metabolism(1902 alkaptonuria biochemical

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