Chapter 13-pt3

Chapter 13-pt3 - Ch 13: 339 - 343 Eukaryotic mRNA I. Intro...

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Ch 13: 339 - 343 – Eukaryotic mRNA I. Intro A. mature, active mRNA: 5’ untranslated leader sequence; coding sequence; 3’ untranslated trailer sequence B. in prokaryotes: RNA transcript functions directly as mRNA molecule; coupled transcription and translation; often polycistronic mRNA C. in eukaryotes: RNA processing: RNA migrates from nucleus to cytoplasm before translation; always monocistronic II. Production of Mature mRNA 1. introns (intervening sequence) present in protein-coding genes 1. RNA Pol II makes 20-30 nucleotides; then capping enzyme adds a 7- methyl (usu) guanine nucleotide to 5’ end a. cap protects mature mRNA from degradation by exonuclease & is impt for binding of ribosome in initial step of translation 2. 3’ end gets 50-250 adenine nucleotides (poly(A) tail no DNA template for) a. required for efficient export of mRNA from nucleus to cytoplasm,
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Chapter 13-pt3 - Ch 13: 339 - 343 Eukaryotic mRNA I. Intro...

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