Chapter 20-pt1 - Chapter 20(Pg 546-548 Control of...

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Chapter 20 (Pg 546-548) Control of Transcription Initiation Intro initiation of transcription under control of promoter (immediately upstream of gene) & enhancers (distant from gene) general transcription machinery which assembles on core promoter alone only capable of basal level of transcription maximal level depends on binding of regulatory proteins to promoter proximal elements and enhancer elements - recruitement of proteins needed to make chromatin accessible to transcription machinery - recruiting transcription machinery to the promoter Chromatin Remodeling (nucleosomes have repressive effect on gene expression b/c access to DNA impeded; removes need for gene repressors in most cases) Repression of Gene Activity by Histones transcriptionally active genes in chromatin have increased sensitivity to DNase I compared w/ transcriptionally inactive genes - means chrom is less highly coiled in these regions
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