Handout 2 - Handout 2 Infection of E coli by Phage virulent...

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Handout 2 Infection of E. coli by Phage λ virulent – replicate, kill, lytic cycle temperate – integration, possible lysogenic cycle lytic cycle: phage enters serves as template for transcription by host RNA Pol phage proteins phage DNA replicates progeny phages assemble host cell lyses lysogenic cycle: phage enters early genes transcribed/translated λ appears, binding to phage operator regions (sht down transcription of all genes except cI, gene for λ repressor) prophage (integrated DNA) in lysogen (host bacteria in which there’s a virus in the DNA) Lytic Reproduction of Phage λ has early, middle, late genes phage DNA – linear initially, circularizes in host w/ sticky cos ends (brings together late genes) at end of transcribing early genes, get to a ρ -dependent termination (stops short of middle genes) early gene products cro product is antirepressor that blocks transcription of cI (prevents synth of repressor)
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Handout 2 - Handout 2 Infection of E coli by Phage virulent...

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