Aplysia2 - Late associative effect: presynaptic and...

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Complex Learning in Aplysia
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Classical Conditioning Classical conditioning must be confirmed by using the right control groups
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CC-2 Some change with US alone (= ?) Large, lasting behavioral change with pairing
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Differential Conditioning--Two CSs
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CC-Physiology Unpaired stimuli do not produce lasting effects in the responses of the sensory or motor neurons
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CC-Physiology2 Paired stimuli do produce lasting effects -- but only in the responses of the motor neurons
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CC-Mechanism How can pairing two stimuli have a bigger effect than presenting them alone? Logically, it must be because of effects at a place where the two signals come together. Not in the interneurons Not in transmission of information through either the sensory or the motor neurons What’s left? The synapse between S and M
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CC-Mechanism Short-term effects: Ca++ from touch joins with action of G-protein to induce more c- AMP than either alone Shock Early associative effect is presynaptic
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Unformatted text preview: Late associative effect: presynaptic and postsynaptic Aplysia Shortcomings • Reductionism--the real behavior isn’t monosynaptic. Multisynaptic excitation and inhibition are important but cannot easily be studied • Mechanism at the synapse is largely inferred (which may lead to incorrect conclusions Principles for Learning 1. Cellular and molecular correlates of learning can be identified 2. Short term changes in behavior involve pathways, synapses and mechanisms that were responsible for the behavior before the learning 3. The changes in the nervous system responsible for learning take place at synapses Principles for Learning 1. Complex learning (like CC) shares mechanisms with simpler learning 2. Within synapses, there are multiple mechanisms that reinforce each other, both to extend the duration of learning and to increase the effects of learning 3. Both pre- and postsynaptic mechanisms are important...
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This note was uploaded on 02/09/2010 for the course BIO 3280 taught by Professor Devoogd, t during the Spring '10 term at Cornell.

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Aplysia2 - Late associative effect: presynaptic and...

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