9-11-09_protein_structure2B

9-11-09_protein_structure2B - Edwards: Why the big secret?...

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Edwards : Why the big secret? People are smart. They can handle it. Kay : A person is smart. People are dumb, panicky dangerous animals and you know it. Fifteen hundred years ago everybody knew the Earth was the center of the universe. Five hundred years ago, everybody knew the Earth was flat, and fifteen minutes ago, you knew that humans were alone on this planet. Imagine what you'll know tomorrow. – Men in Black
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A “practical” reason to understand cell biology Video games of course! (Spore creature design)
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Announcements Online Quiz #2 is due today at noon. http://blog.wired.com/wiredscience/2008/09/biologists-on- links to a cool article describing synthetic biology research Review questions for exam 1 (next Friday) will be posted on Blackboard today
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Nucleic Acid Structure Phosphate and sugar form the backbone. The nitrogenous base carries the “information” Phosphate, charged and hydrophilic Ribose or deoxyribose Adenine (shown) Thymine (DNA) Guanosine Cytosine Uracil (RNA)
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Phosphates and sugars make up the nucleic acid backbone. Bases are linked to the sugars. The phosphate is normally linked to the 5'- carbon of the sugar The nitrogenous base is attached to the sugar's 1'-carbon Monomers polymerize when sugar 3'-OH is linked by ester bond to 5'-phosphate of next nucleotide in chain ( 3' - 5' phosphodiester linkage ); so nucleotides are joined by sugar-phosphate linkages the backbone can be used as a mechanical scaffold for making nanomaterials, such as bioactive nanowires
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Cytosine Adenine P P P P Guanine Thymidine P O Thymidine Cytosine A denine G uanine O O O O In RNA, uracil substitutes for thymidine (thymine). Bonds always made between one purine and one pyrimidine, keeping width nearly constant A-T are bonded by two H-bonds. G-C are bonded by three H-bonds.
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9-11-09_protein_structure2B - Edwards: Why the big secret?...

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