{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

9-17-08_lecture_bioenergetics3A

9-17-08_lecture_bioenergetics3A - Tick's Brain Tick this is...

Info icon This preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Tick's Brain : Tick, this is your mind speaking. Tick : Oh. Hello. Tick's Brain : Sorry I haven't been around much lately but I'm easily distracted by shiny objects. Tick : Arthur, you have no historical perspective. Science in those days worked in broad strokes. They got right to the point. Nowadays, it's all just molecule, molecule, molecule. Nothing ever happens big.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Announcements First test this Friday, Sep. 19, 7:30 am in Matthews 210 (this room). Exam will cover through Monday’s lecture. Equations will be provided. Calculators are not permitted. Review session in MJIS 1001, Sep. 18 from 7:30-9 pm. The TAs and I will answer specific questions but not lecture.
Image of page 2
Completed amino acid sequences are either released by the chaperone or brought to a new chaperone Many proteins, once completed, can fold into their native shape Large proteins can be transferred to a chaperonin (5) Chaperonins are cylindrical and act as protein isolation chambers to shield protein during folding.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Steps in GroEL/GroES chaperoning of protein folding 1) Protein enters and binds to hydrophobic proteins in GroEL. 2) Binding of ATP allow binding of GroES, which increases size of chamber and dissociates protein from GroEL 3) After 10-15 seconds, GroES dissociates from GroEL, and the protein is ejected. 4) A misfolded protein may undergo the cycle again
Image of page 4
Bioenergetics
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Review of Bioenergetics First law: Energy cannot be created or destroyed Second law: The entropy of the universe is increasing Entropy has multiple formulations to quantify the changes in the “order” and “disorder”, of the system The Gibbs free energy, ΔG=ΔH-TΔS, determines whether a reaction is energetically favorable Rule of thumb: Every system seeks to achieve a minimum of free energy
Image of page 6
According to the second law of thermodynamics, an increase in entropy is inevitable A increase in heat Q, will result in an increase in entropy S, given by ΔS=ΔQ/T or ΔQ=TΔS
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Three other formulations of entropy give insight into how to think about entropy Boltzmann entropy, S=k B ln Ω , where k B is Boltzmann’s constant and Ω is the number of microstates in the system Gibb’s entropy, S=-k B Σ i p i ln p i , where pi is the probability of being in the ith microstate. This is a more general form of
Image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern