9-17-08_lecture_bioenergetics3A

9-17-08_lecture_bioenergetics3A - Tick's Brain: Tick, this...

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Tick's Brain : Tick, this is your mind speaking. Tick : Oh. Hello. Tick's Brain : Sorry I haven't been around much lately but I'm easily distracted by shiny objects. Tick : Arthur, you have no historical perspective. Science in those days worked in broad strokes. They got right to the point. Nowadays, it's all just molecule, molecule, molecule. Nothing ever happens big.
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Announcements First test this Friday, Sep. 19, 7:30 am in Matthews 210 (this room). Exam will cover through Monday’s lecture. Equations will be provided. Calculators are not permitted. Review session in MJIS 1001, Sep. 18 from 7:30-9 pm. The TAs and I will answer specific questions but not lecture.
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Completed amino acid sequences are either released by the chaperone or brought to a new chaperone Many proteins, once completed, can fold into their native shape Large proteins can be transferred to a chaperonin (5) Chaperonins are cylindrical and act as protein isolation chambers to shield protein during folding.
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Steps in GroEL/GroES chaperoning of protein folding 1) Protein enters and binds to hydrophobic proteins in GroEL. 2) Binding of ATP allow binding of GroES, which increases size of chamber and dissociates protein from GroEL 3) After 10-15 seconds, GroES dissociates from GroEL, and the protein is ejected. 4) A misfolded protein may undergo the cycle again
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Bioenergetics
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Review of Bioenergetics First law: Energy cannot be created or destroyed Second law: The entropy of the universe is increasing Entropy has multiple formulations to quantify the changes in the “order” and “disorder”, of the system The Gibbs free energy, ΔG=ΔH-TΔS, determines whether a reaction is energetically favorable Rule of thumb: Every system seeks to achieve a minimum of free energy
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According to the second law of thermodynamics, an increase in entropy is inevitable A increase in heat Q, will result in an increase in entropy S, given by ΔS=ΔQ/T or ΔQ=TΔS
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Three other formulations of entropy give insight into how to think about entropy Boltzmann entropy, S=k B ln Ω , where k B is Boltzmann’s constant and Ω is the number of microstates in the system Gibb’s entropy, S=-k B Σ i p i ln p i , where pi is the probability of being in the ith microstate. This is a more general form of Boltzmann’s entropy that does not assume all microstates are
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This note was uploaded on 02/09/2010 for the course BIOL 230 taught by Professor Bartlett,e during the Fall '08 term at Purdue University.

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9-17-08_lecture_bioenergetics3A - Tick's Brain: Tick, this...

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