10-10-08_lecture_neuroA

10-10-08_lecture_neuroA - The brain is a wonderful organ;...

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The brain is a wonderful organ; it starts working the moment you get up in the morning and does not stop until you get into the office. Robert Frost Tick : You know. .. I've heard the smarter you are, the more wrinkly your brain. And your guys' brains must be the wrinkliest. Oh, sure, ordinary Joes like me and Arthur here, maybe our brains are a little on the smooth side. But you don't have to be a genius to know that evil is bad. And good isn't.
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Announcements Quiz 4 due Wednesday 10/15 at noon, not Monday. Dates for cell simulation project will be pushed back: TBA Test will be ?????? The chemistry Nobel is for a breakthrough in biology. Osamu Shimomura, Martin Chalfie , and Roger Y. Tsien , won for the discovery and development Green Fluorescent Protein (GFP). Excellent GFP site that explains the chemistry and shows some great pictures from applications of GFP. http://www.conncoll.edu/ccacad/zimmer/GFP-ww/GFP- 1.htm
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The GFP brainbow! Color variants created by differential expression of variants of GFP, including yellow (EYFP), cyan (mCFPm), and red (tdTomato). In this example, the colors are not cell-type specific. Livet, Lichtenberg, and Sanes, Harvard U
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Glucose transport during insulin stimulation Solute binds to transporter molecule No energy required Bidirectional, follows concentration gradient In this example, glucose binds to the transporter Like enzymes, transporters are highly specific Slower than channels, faster than passive diffusion Mueckler 1994
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Active transport: Na+/K+-ATPase example Na + out =150 mM, Na + in =15 mM : E Na =+60 mV K + out =5 mM, K + in =100 mM : E K = -78 mV These large concentration imbalances are maintained by the Na/K pump 3 Na+ are pumped out for each 2 K+ that come in, so the pump is electrogenic and will also create a charge difference across the membrane
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Na+ binds on intracellular side and ATP is hydrolyzed to start the exchange 3 Na+ ions bind within the pump, which is in the resting (E1) conformation
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10-10-08_lecture_neuroA - The brain is a wonderful organ;...

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