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11-04-09_DNA_replicationA

11-04-09_DNA_replicationA - Today's lecturer Andrew...

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Today's lecturer: Andrew Woolley (TA) Biology PhD student Work with Dr. Kevin Otto Research brain’s biological response to implanted devices Oligodendrocytes Microglia
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Replication of DNA Photograph: The Watson Archive .
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Last time… DNA structure Simple chemical code forms blueprints for all life Features Double helix Anti-parallel strands A-T, G-C complements H-bonds, easily broken www.science.uwaterloo.ca/~cchieh/
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Each generation needs a genome Blueprints need a copier to copy the blueprints Essential to the definition of ‘life’ `… how is this done? Photograph: The Watson Archive .
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Problems Human genome ~3 billion nucleotides Every new cell needs a copy (except red blood cells) Knowing the structure, we can hypothesize how DNA might be duplicated …three example methods…
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Potential duplication methods Conservative Replication Semiconservative Replication Dispersive Replication What basic way might these two DNA strands be duplicated? …some ideas…
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Potential duplication methods Semiconservative Replication •Strands separately duplicated and stay with new nucleotides pairing •Each daughter duplicate has one DNA strand from parent structure Red = New DNA Black= Original DNA
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Potential methods Conservative Replication •Copy made from parent templates, with original DNA pair maintained Keeps original copies together, which could help Red = New DNA Black= Original DNA
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Potential methods Dispersive Replication •Copy made from parent templates, with original DNA pair maintained Keeps original copies together, which could help Red = New DNA Black= Original DNA •Fragments are made of the blueprints Daughters contain old and new DNA •Would avoids unwinding and anti-parallel problems
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