11-23-09_celltraffickingA - Todays lecture Guest Lecture by...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Today’s lecture “Guest” Lecture by Cal Rabang (TA) Biomedical Engineering Grad Student (Dr. Bartlett’s lab) Research Interests: Neural representations of sound Computational neuron modeling Intracellular whole-cell recording
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cellular trafficking Kid #3 : Hey, mister. Ain't you got a car? Eddie Valiant : Who needs a car in L.A.? We have the best public transportation system in the world. Judge Doom : A few weeks ago I had the good providence to stumble upon a plan of the city council. A construction plan of epic proportions. We're calling it a freeway. Eddie Valiant : Freeway? What the hell's a freeway? Judge Doom : Eight lanes of shimmering cement running from here to Pasadena. Smooth, safe, fast. Traffic jams will be a thing of the past. From “Who Framed Roger Rabbit?”
Background image of page 2
Last time…(besides the exam) Gene Expression Translation DNA mRNA tRNA Proteins Gene expression control Transcription factors Operons
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Proteins, straight off the assembly line… Once a protein is made, where does it go? Most are constructed by ribosomes in the cytosol, and remain there Others are needed in specific organelles or on the cell membrane Examples: Hormone receptor proteins Digestive enzymes RNA/DNA polymerases Extracellular matrix components How are these proteins sorted, and afterwards, how are they delivered?
Background image of page 4
Figure 15-5 Essential Cell Biology (© Garland Science 2010)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Trafficking in the endomembrane system Complex cytoplasmic membrane and tubule network for packaging and routing proteins and lipids to their proper destinations Consists of endoplasmic reticulum (ER) and Golgi complex Many proteins are synthesized by ribosomes on the rough ER Proteins and lipids are modified, packaged, sorted, and transported by the Golgi complex Proteins and chemicals such as digestive enzymes are often packaged in vesicles, which fuse with the plasma membrane and are secreted
Background image of page 6
Movements of materials within cells are tightly regulated Constitutive secretion: Always on, unregulated, mainly extracellular matrix and plasma membrane Regulated secretion: Materials are synthesized and stored in membrane bound packages until stimulated to transport to target (e.g. hormones and neurotransmitters) Proteins, lipids, and carbohydrates all participate in secretory pathways
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Figure 15-27 Essential Cell Biology (© Garland Science 2010)
Background image of page 8
Cell Ex: When it absolutely, positively has to be inserted right 1) Unassembled package is brought to FedEx 2) Sorted and barcoded to indicate its final destination 3) Routed appropriately for long-distance air or ground shipping and prepared for the shipping 4) Shipped from local site to transport hub, where it is sorted
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/09/2010 for the course BIOL 230 taught by Professor Bartlett,e during the Fall '08 term at Purdue University-West Lafayette.

Page1 / 28

11-23-09_celltraffickingA - Todays lecture Guest Lecture by...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online