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11-30-09_signalingGprotB

11-30-09_signalingGprotB - Waiting for the sign Main...

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Waiting for the sign: Main classes of intracellular signaling pathways Dr. Egon Spengler : Vinz, you said before you were waiting for a sign. What sign are you waiting for? Louis : Gozer the Traveler. He will come in one of the pre-chosen forms. During the rectification of the Vuldrini, the traveler came as a large and moving Torg! Then, during the third reconciliation of the last of the McKetrick supplicants, they chose a new form for him: that of a giant Slor! Many Shuvs and Zuuls knew what it was to be roasted in the depths of the Slor that day, I can tell you!
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Announcements Research Article Summary 2 due this Friday, 12/4 at noon A SafeAssign dropbox for the assignment has been created on Blackboard called “Bio 230 2009 Research Article Summary 2” Course evaluations can be submitted starting today until December 13.
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Trafficking in the endomembrane system Complex cytoplasmic membrane and tubule network for packaging and routing proteins and lipids to their proper destinations Consists of endoplasmic reticulum (ER) and Golgi complex Many proteins are synthesized by ribosomes on the rough ER Proteins and lipids are modified, packaged, sorted, and transported by the Golgi complex Proteins and chemicals such as digestive enzymes are often packaged in vesicles, which fuse with the plasma membrane and are secreted
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Hey bud, let’s party! Schematic of a secretory pathway Left: Biosynthetic/secretory pathway Right: Endocytic pathway: taking in substances from outside. Secretory pathway is: 1) Nucleus 2) rough ER (RER) 3) ER-Golgi intermediate complex (ERGIC) 4) cis Golgi network 5) trans Golgi network 6) vesicle 7) fusion with target membrane Packaging and targeting is achieved through protein and/or carbohydrates that can be used to sort molecules or vesicles
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The Golgi complex, or Golgi apparatus Golgi complex localizes near nucleus ER to ERGIC (Endoplasmic reticulum Golgi Intermediate Complex) Consists of cis-side near ER and trans-side near cytoplasm Stacks of cisternae connected by tubules. Cis-Golgi network (CGN), mostly receiving and sorting Carbohydrate modifications in whole complex, but many in medial cisternae Proteins put in appropriate vesicles (membrane or organelle bound) in the trans-Golgi network (TGN)
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Protein orientation is maintained throughout the transport network Most integral membrane proteins in RER have sugars attached to them on luminal side
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