answers2006-1 - Principles of Drug Action (BIO 365) Test #1...

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Principles of Drug Action (BIO 365) Test #1 Name:_____________________________ February 15, 2006 Each of the 16 multiple choice questions is worth 0.75 marks out of 30 . 1. The sedative flunitrazepam has been given the street name “Roofies”. “Roofies” is what kind of drug name? A. Proprietary. B. Non-proprietary. C. Chemical. D. Generic. E. Common. 2. The chemical modification of the mold-derived antibiotic penicillin to create the new antibiotic oxacillin means that oxacillin is an example of a A. Pure compound. B. Galenical. C. Semi-synthetic compound. D. Synthetic compound. E. None of the above. 3. Which one of the following statements is TRUE ? A. A scopolamine patch for seasickness is an example of a sublingual administration of a drug. B. An intrathecal injection is a form of topical drug administration. C. Drugs administered via suppository are subject to the first-pass effect. D. Drugs administered sublingually tend to be absorbed slowly. E. Drugs administered subcutaneously are quickly absorbed. 4. Aquaporins are A. Water-filled channels that allow drug molecules with low Pm/b values to cross cell membranes. B. Water-filled channels that allow drug molecules with high Pm/b values to cross cell membranes. C. Proteins that form pores between cells. D. A form of drug transport that involves ATP hydrolysis. E. Proteins found in blood that bind drug molecules, thus decreasing their rates of elimination. 5. Assume that ethane (CH3CH3) has a membrane/buffer partition coefficient of 100. If adding a hydroxyl group to an aliphatic molecule like ethane changes its membrane/buffer partition coefficient by a factor of 0.1, what will be the membrane partition coefficient of ethanol (CH3CH2OH)? A. 110 B. 90 C. 10 D. 100.1 E. 99.9 6. Which one of the following statements is FALSE ? A. Salicylic acid will be more rapidly absorbed at a pH of 2 than a pH of 9. B. Organic amines (bases) are more rapidly absorbed in the small intestine. C. Organic acids are more likely to be found in the uncharged form in the stomach than in the small intestine. D. The organic base morphine will be more rapidly absorbed at a pH of 5 than a pH of 10. E. Organic bases are more likely to be found in the charged form in the stomach than in the small intestine.
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7. If the GFR is 125 ml/min but a drug’s clearance is 200 ml/min this means A. the drug must be reabsorbed as well as filtered. B. the drug must be secreted as well as filtered. C. the drug must be filtered especially thoroughly. D. the drug must be decreasing blood perfusion of the kidney E. the patient must be bleeding internally in order to explain this rapid clearance. . 8.
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answers2006-1 - Principles of Drug Action (BIO 365) Test #1...

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