answers2006-2 - Principles of Drug Action (BIO 365) Test #2...

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Principles of Drug Action (BIO 365) Test #2 Name:_____________________________ March 24, 2006 Each of the 16 multiple choice questions is worth 0.75 marks out of 30 . 1. Let’s start off with a really easy gift question. Ultimate carcinogens produce cancers by binding to A. Protein B. DNA C. RNA D. Lipid. E. Carbohydrate 2. p53 is which one of the following? A. A tumor suppressor B. An oncogene C. A proto-oncogene D. A cancer-causing gene E. A type of cancer cell 3. A physician sees a 12 year old boy who weighs 50 kg. The adult dose of the drug he wishes to prescribe is 100 mg. How much should he give the boy according to both Young’s Rule and the Body Surface Rule? A. 85 g according to Young’s Rule and 50 g according to the Body Surface Rule. B. 50 g according to Young’s Rule and 85 g according to the Body Surface Rule. C. 100 g according to Young’s Rule and 50 g according to the Body Surface Rule. D. 50 g according to Young’s Rule and 100 g according to the Body Surface Rule. E. 75 g according to Young’s Rule and 85 g according to the Body Surface Rule. 4. An individual dies of an overdose due to taking alcohol and barbiturates simultaneously. This is an example of what kind of drug interaction? A. External B. Physicochemical C. Physiological D. Pharmacodynamic E. Pharmacokinetic 5. In a recessive disorder, if the frequency of a particular allele is 0.15, what percentage of people in the population are carriers of that allele? Hint: In your calculation don’t include people who are homozygous and actually have the disorder. A. 12.8% (0.15 x 0.85) B. 25.5% (0.15 x 0.85 x 2) C. 15% D. 72.3% (0.85 x 0.85) E. 2.3% (0.15 x 0.15)
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6. Which one of the following statements is TRUE ? A. The acetylcholine molecule can convert between the cis and trans forms because of the double bond in its structure. B. Atropine is an antagonist at muscarinic, but not nicotinic, ACh receptors because its chemical structure permits it a great deal of intramolecular rotation. C. Atropine can adopt either the cis or trans form and this determines whether it will interact with muscarinic or nicotinic acetylcholine receptors. D Optical isomers of drugs are those that have at least three points of attachment to receptors, and have either a centre or plane of asymmetry. E The levo ( l ) isomers of morphine and methorphan are non-addicting. 7. Which one of the following statements is TRUE ? A. There are no known antagonists of metabotropic receptors. B. Metabotropic receptors act by opening an ion channel that is an intrinsic part of the receptor/channel complex. C. Metabotropic and ionotropic receptors for the same neurotransmitter have no common evolutionary history, in terms of amino acid sequence similarities.
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answers2006-2 - Principles of Drug Action (BIO 365) Test #2...

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