answers2006-final - Name:_ Principles of Drug Action (BIO...

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Name:____________________________ Principles of Drug Action (BIO 365D) Final Exam May 13, 2006 Each of the 30 multiple choice questions is worth 0.5 marks (for a total of 15 out of 40) . 1. Which one of the following routes of drug administration DOES NOT involve a needle? A. Intrathecal. B. Percutaneous C. Subcutaneous D. Sublingual E. Intraperitoneal 2. Epithelial membranes of the skin, g.i. lumen, cornea, bladder seal off the outside world from body tissues and fluids because epithelial cells are joined to one another by? A. Connexins B. Occluding zonulae C. Aquaporins D. Maculae E. Gap junctions 3. Which statement concerning the liver or kidney is TRUE? A. The hepatic artery supplies the majority of blood flow to the liver. B. The hepatic artery is responsible for bringing blood to the liver after it has perfused the digestive system. C. In the kidney, most solute reabsorption occurs in the loop of Henle. D. Solute reabsorption can occur either actively (expenditure of energy) or passively. E. ADH (vasopressin) makes the urine more dilute. 4. Which one of the following statements is FALSE ? A. Skin and bones are two examples of vessel-poor groups (VPG) of tissues into which drugs would be expected to partition slowly. B. A patient suffering from hypoalbuminemia will show increased free (unbound) drug levels, for some drugs. C. Cytochrome P450 enzymes exhibit low substrate specificity. D After intravenous injection, the injected drug travels as a bolus for 2-3 circulation times. E Phase I and phase II drug biotransformation reactions result in the metabolite having a higher membrane:buffer partition coefficient than the parent drug. 5. Which one of the following equations is INCORRECT ? A. C t = C 0 × e -kt B. t 1/2 = 0.693 / k C. V = Q / (k × C ss ) D. Cl = C ss / Q E. V = Dm / (C tox - C ther )
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Name:____________________________ Bound Bound/free B max B max A B 6. If you hook up a patient to an i.v. bag and start infusing him with a drug that has a half-life of 2 hours, approximately how long will it take until a steady state concentration (within a few percent of the true steady state) is achieved? A. 1 hrs B. 2 hrs C. 10 hrs D. 20 hrs E. You cannot determine this from the information provided. 7. You construct effective dose and toxic dose concentration-response curves for a drug. It has an ED1 of 5 nM, an ED50 of 250 nM and an ED99 of 1000 nM. It also has a TD1 of 100 nM, a TD50 of 500 nM and a TD99 of 1,000 nM. Calculate the drug’s therapeutic index (TI) and certain safety factor (CSF). A. TI = 2 and CSF = 0.1 B. TI = .5 and CSF = 10 C. TI = 0.1 and CSF = 2 D. TI = 10 and CSF =0.5 E. TI = 0.1 and CSF = 0.05 8. Which one of the following statements about binding assays is TRUE ? A.
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This note was uploaded on 02/10/2010 for the course BIO 365D taught by Professor Mihic during the Spring '08 term at University of Texas.

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answers2006-final - Name:_ Principles of Drug Action (BIO...

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