Exam 2 Fall 2009vE

Exam 2 Fall 2009vE - Average of both versions B and E =...

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Average of both versions B and E = 69.7% Principles of Cell Biology Exam 2 March 26, 2009 Directions : There are 75 questions in this exam with only one correct answer for each question. Abbreviations: RER – rough endoplasmic reticulum; SER – smooth endoplasmic reticulum; SRP – signal recognition particle; NO – nitric oxide; GPCR – G protein coupled receptor; TGN – Trans Golgi Network. 1. Which component of the receptor tyrosine kinase system is often mutated in cancer cells and, as such, constitutively controls cell division and is not controlled by GDP/GTP binding? a. SH3 b. Ras c. Sos d. SH2 e. GRB2 2. Collagen is secreted through the constitutive secretory pathway. Thus, it is not synthesized in or passes through which areas? a. trans Golgi Network b. cis-Golgi c. rough endoplasmic reticulum d. late endosome e. cytosol 3. Mudd and Mudd did an interesting series of experiments as they pursued the molecular nature of cell membranes. They found that a mixed group of cells (red blood cells and white blood cells) partitioned differently in a water/oil mixture. They concluded from this experiment that a. cell membranes may be composed of phospholipid bilayers, not monolayers b. some cells may contain more cell membrane associated proteins than others c. lipid soluble dyes penetrate cells more readily than non-lipid dyes d. the Dave Matthews Band’s 2009 tour will be the best in the band’s history e. the cell membrane is composed of a mosaic of proteins 4. If a protein has a stromal import sequence it means that a. it was synthesized on the RER b. it has a targeting sequence on the carboxy end of the protein c. it is being transported to chloroplasts d. it is being transported to peroxisomes e. none of the above 5. Rod photoreceptor signal transduction (the conversion of light to a change in transmembrane potential) does not involve a. cAMP b. opsin/rhodopsin c. calcium d. cGMP phosphodiesterase
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e. ion channels in the outer rod plasma membrane 6. Orphan receptors are ones that a. have no known ligands b. are of little interest to scientists c. bind steroids d. always trimerize when bound by ligand e. all of the above 7. Which type of receptor is the most commonly studied receptor type in the pharmaceutical industry? a. GPCRs b. Steroid receptors c. NF- κ B receptors d. Notch receptors e. Wnt receptors 8. Insulin binds to its receptor and immediately autophosphorylation occurs. What is autophosphorylated? a. insulin b. the β subunit of the insulin receptor c. the soluble insulin-dependent protein kinase d. Ras e. Hexoses that are transported through the GLUT4 channel. 9. Which of the following junctions is critically important for the attachment of epithelial cells to a basal lamina (basement membrane)?
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Exam 2 Fall 2009vE - Average of both versions B and E =...

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