Midterm 2 reactions

Midterm 2 reactions - Mid Term 2 Reaction List 1 Amine...

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Amine Forming Reactions Ammonia with alkyl halides: NH 3 + R-X Synthesis: Not Useful (product mixture) Predict the product: Likely to see this. Remember to include all products Mechanism: Simple S N 2 reaction. Should be second nature Other: Know why it keeps reacting. Why is the more substituted amine more nucleophilic? Book Pages: 969-970 Reducing Amides: Synthesis: Very Useful Predict the product: Possible to show up, if in acid remember to protinate the -NR 2 Mechanism: Not too important. Treat it as two H: - attacking. Other: Good way to make a primary amine Book Pages: 975 Hoffmann Rearrangement: Synthesis: Good way to lose a carbon Predict the product: Good way to make a primary amine Mechanism: Know this mechanism Other: Know the conditions of the reaction Book Pages: 975, 934-935 Mid Term 2 Reaction List 1
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Amine Forming Reactions 2 Mannich Reaction: Synthesis: Can be useful, but is very specific Predict the product: Trick problem alert. If the indicated H is gone it wont react. Mechanism: Know this mechanism Other: Know what it means to be enolizable Book Pages: 977-978 Reducing Nitriles: Synthesis: Very good step in a synthesis. Very Useful Predict the product: If in acid it can protinate. If acid is missing Al will be a part of the product Mechanism: Not too important, again treat it like H- attacking Other: Be aware of conditions Book Pages: 971 Reducing Nitros: Synthesis: Very useful step. Often used after adding NO 2 to benzene Predict the product: Not too likely. Watch out for acid that makes it protinated Mechanism: Not too important Other: Watch your conditions Book Pages: NA Mid Term 2 Reaction List 2
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Amine Forming Reactions 3 Reducing Azides: Synthesis: Not a very useful step Predict the product: Most likely to show up here if anywhere Mechanism: Not too important Other: Watch protination in acid Book Pages: 971 Reductive Amination: Synthesis: Can be a useful final step if you have a pesky ketone around
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This note was uploaded on 02/10/2010 for the course BIO NPB taught by Professor Furlow during the Spring '10 term at UC Davis.

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Midterm 2 reactions - Mid Term 2 Reaction List 1 Amine...

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