NHFinalA'04

NHFinalA'04 - Biological Sciences 101 Dr Neil Hunter Dr...

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1 Biological Sciences 101 Name_________________________ Dr Neil Hunter Dr Mark Sanders ID___________________________ Fall Quarter 2004 FORM A FINAL EXAM This exam contains eight questions worth a total of 160 points. Read the questions carefully before answering. If you do not understand a question please don’t hesitate to ask for clarification. Please show all your work to get full credit. The best of luck!
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2 Biological Sciences 101 Name_________________________ Dr Neil Hunter Dr Mark Sanders ID___________________________ Fall Quarter 2004 FORM A Final Exam Question Points 1 ______ 2 ______ 3 ______ 4 ______ 5 ______ 6 ______ 7 ______ 8 ______ TOTAL ______
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3 Question 1. ( 22 pts) i) Explain the difference between positive and negative regulation (write two sentences only please). 4 pts ii) The following table represents a series of E. coli strains that are partial diploids for the lac operon. Indicate whether or not the β -Galactosidase and Permease proteins are expressed for each cross under each condition (with or without IPTG). Write a “+” for expression and a “–” for no expression. 12 pts -Galactosidase Permease Experiment number Genotype IPTG + IPTG IPTG + IPTG 1 I + P + O + Z + Y / F’ I + P + O + Z Y + 2 I + P O Z Y / F’ I P + O + Z + Y + 3 I P + O C Z + Y / F’ I + P O + Z Y + 4 I + P + O + Z + Y / F’ I P + O C Z Y + 5 I P + O + Z Y / F’ I S P + O + Z Y + 6 I P + O C Z + Y / F’ I + P + O + Z Y + iii) Classify the experiments based on whether they reveal function in trans, function in cis, both trans and cis or neither. 6 pts Trans: Cis: Trans and Cis: Neither:
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4 Question 2. (20 pts) Hemophilia is a sex-linked recessive disorder characterized by prolonged blood clotting time. The pedigree below shows blood-clotting phenotypes for six members of a family. From the information available, answer the following question. i) If II-2 marries a man with normal blood clotting, what is the chance of her first child being a hemophilic boy? Show your work. 4 pts ii) If II-2 marries a man with normal blood clotting and her first child is hemophilic, what is the chance that her second child will have hemophilia? Explain your
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This note was uploaded on 02/10/2010 for the course BIO NPB taught by Professor Furlow during the Spring '10 term at UC Davis.

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NHFinalA'04 - Biological Sciences 101 Dr Neil Hunter Dr...

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