disturbances of blood flow and body fluids

disturbances of blood flow and body fluids - Disturbances...

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Disturbances of Blood Flow and Body Fluids
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Blood Coagulation
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Normal clotting There are numerous steps in the clotting process Sequential activation of enzymes generates thrombin Thrombin converts the plasma protein fibrinogen to fibrin Fibrin forms the framework of the clot
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Clotting Cascade
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Disorders of Clotting
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Failure to clot Examples of causes Hemophilia Decreased platelet count Decreased vitamin K Decreased plasma protein levels
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Disorders of Clotting
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Increased tendency to clot Risk factors (examples) Slow blood flow (stasis) Prolonged bed rest or air travel Atherosclerosis Post operative patients Oral contraceptives Estrogen replacement therapy Paralysis Pregnancy Smoking Obesity
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Terminology
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Thrombus (thrombosis) – a blood clot that forms inside a blood vessel or the heart Embolus (embolism)- anything abnormal traveling through the circulatory system Examples: blood clot, air, fat, foreign body, tumor cell, bacteria
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Medical Implications of Thrombus and Embolus
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May cause: Cerebrovascular accident (CVA) Heart attack (myocardial infarction) DVT Pulmonary Embolus
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Heart
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disturbances of blood flow and body fluids - Disturbances...

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