9-22-09 & 9-24-09

9-22-09 & 9-24-09 - Injury, Inflammation and...

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Unformatted text preview: Injury, Inflammation and Healing See picture Cellular Aging Cells need to be healthy to heal Aging can affect a cells ability to heal Aging population Slower wound healing Decreased resistance to infection Cell Injury The bodys reaction to cell injury is inflammation Purpose of Inflammation Removal of injurious agent skin gets very hot and burn off bacteria; get rid of whats causing injury Removal of cellular debris so healthy tissue can grow Initiation of healing Sometimes tissues can not heal with like tissue, but instead heal with connective tissue ex: sprain of a ligament (like lateral ankle ligaments) heal with scar tissue which is connective tissue, not ligamentous tissue Mechanisms of Cell Injury (Causes of Cell Injury) Ischemia lack of blood supply Infectious Agents flu, cold, bronchitis, Immune or Allergic Reactions Lupus - being allergic to ones self Genetic Factors - inherited Nutritional Factors lacks vitamin C leads to scurvy; lack of B vitamins leads to beri beri Physical Factors sprains, strains, bruises Chemical Factors chemical burns Ischemia Decreased blood flow to a tissue or organ Causes hypoxia or anoxia Hypoxia decreased levels of O 2 Anoxia total lack of O 2 Lack of O 2 results in decreased ATP, which results in cellular swelling and compromised cellular function - cells wont work properly Ex: muscles tendons or brain tissue wont have same elasticity and will be weaker if experience episodes of decreased oxygen Infectious Agents Bacteria Viruses Mycoplasms Fungi Rickettsiae Protozoa Helminths Above cause cellular injury and/or death if left untreated Infectious Agents Sepsis Sepsis infection that has spread to the blood very serious Septic Septic Shock Shock cardiovascular collapse due to sepsis Cellular injury results from Inflammation reaction Immune system response Release of toxins from the infectious agent make the cell injury even worse Disturbance of cellular mechanisms Immune Reactions Some immune reactions activate inflammatory cells and cause swelling Ex: Hay fever Others destroy on a cellular level Ex autoimmune diseases destroying your own tissues or organs Genetic Factors Genetically caused chromosomal mutations may cause cellular injury or death Examples Sickle Cell Anemia disease of RBCs Huntingtons Chorea inflammation in the brain Nutritional Factors Proper nutrition is needed for healing Most important are protein and Vitamin C Decreased protein intake is called kwashiorkor or marasmus children get swollen bellies because of abnormal osmosis in the circulation due to lack of protein Vitamin C Deficiency connective tissue symptoms Decreased collagen tissue strength collagen is the cement that holds you together...
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9-22-09 & 9-24-09 - Injury, Inflammation and...

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