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Week 7 Endocrine

Week 7 Endocrine - Hypothalamus • Hypothalamic neurons...

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Unformatted text preview: Hypothalamus • Hypothalamic neurons produce ADH and oxytocin • Transports these hormones along axons (nerves) within the infundibulum and releases them into the circulation at the neurohypophysis (posterior pituitary) Mechanisms of Intercellular Communication • Direct communication - gap junctions • Paracrine communication - through extracellular fluid • Endocrine communication - through circulatory system • Synaptic communication - across synaptic clefts Classes of Hormones • Amino acid derivatives • Peptide hormones • Lipid derivatives Classes of Hormones Amino Acid Derivatives • Hormones synthesized from the amino acids tyrosine and tryptophan • Tyrosine derivatives - thyroid hormones (T3, T4), epinephrine, norepinephrine, and dopamine • Tryptophan derivative is melatonin Classes of Hormones Peptide Hormones • Peptide hormones are chains of amino acids • Usually synthesized as inactive hormones that become activated • 2 groups – glycoproteins short polypeptide chains to proteins • This group includes all the hormones secreted by the hypothalamus, heart, thymus, digestive tract, pancreas, and neurohypophysis, and most of the hormones secreted by the adenohypophysis Classes of Hormones Peptide Hormones - Glycoproteins • TSH - thyroid stimulating hormone • LH • FSH • Epo Classes of Hormones Peptide Hormones - other group • ADH • Oxytocin • GH - Growth hormone • PRL - prolactin • Insulin • PTH Classes of Hormones Lipid Derivatives • Eicosanoids • Leukotrienes • Steroid hormones Classes of Hormones Lipid Derivatives - Steroid Hormones •...
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Week 7 Endocrine - Hypothalamus • Hypothalamic neurons...

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