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lecture week 4 - Bilirubin RBC gets engulfed and broken...

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Bilirubin 
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RBC gets engulfed and broken down by a  phagocyte  Hemoglobin molecule gets broken down  The globular proteins are broken down into  amino acids which get recycled  Each heme unit loses its iron and is converted  to biliverdin  Biliverdin is converted into biliruibn  Bilirubin is excreted in bile and kidneys  Iron is transported by transferrin and goes 
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back to the liver 
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Macrophages 
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In spleen, liver, and bone marrow  Break down RBCs  Bilirubin goes into the liver and then small  intestines or kidneys 
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Negative feedback regulation of erythropoiesis 
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get pic 
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Anemia  Causes 
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Dietary deficiency of iron, B12 or folic acid  Red bone marrow failure - like from  chemotherapy  Epo - cloning and biogenetics  Destruction of red blood cells 
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Formation of RBCs 
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Erythropoietin (Epo) stimulates formation of erythroblasts  which forms red blood cells 
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Platelet Formation 
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