Test 1 2007 key and test - 9-5-07 Key to Test 1 1. False...

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Unformatted text preview: 9-5-07 Key to Test 1 1. False 24A. 3 2. False 24B. 4 3. True 24C. 1 4. False 25A. 5 5. True 25B. 1 6. True 26A. 4 7. True 26B. 3 8. 3 26C. 4 9. directly 26D. 3 10. ethylene glycol 26E. 3 11. hydrogen bonding 27A. W ion—dipole 27B. L 12. intravenous 27C. W 13. low surface area 27D. W limited water 27E. L 14A. 1 14B. 2 14C. 3 15. elalaprilat 16. stomach 17. small intestine 18A. A 18B. A 18C. L 18D. L 19A. PH 19B. A 19C. V 19D. V 20A. 2, 3 20B. 3 20C. 5 21. Strychnine is in its water soluble form at pH 1.2 and is not absorbed. It is in its lipid soluble form at pH 8.5 and is absorbed. 22. l 23. 2 de [ d’ Lat—wood C -— C _ g b _ DmAmRm/aq[ J 1% Q ?* Ghaammcu _ co _ Q Q—CHfiHzfl-NCH —CO — N coo” 400“ coo" ooocuzcu, Enalapril Enalaprilat Daunorubicin Hydrochloride 0 on 0 Gr'meofulvin : Ha "9° a "a? .. I“ 3 moi“, Oxadllin Sodium Levodopa 0 :mm ./ Dunk ° "‘° Oxazepam . Test 1 IPPH 362 Name 9/5/07 Seat Each answer is worth two points. No partial credit. 1. Nutritionals have been regulated by the FDA since 1994. (true, false) 2. A drug having a high melting point is usually very water soluble. (true, false) 3. Once a day megadoses of vitamin C is an inefficient and wasteful method of dosing vitamin C. (true, false) 4. Drugs which are weak acids exist in their more water soluble form in the stomach and in their more lipid soluble form in the small intestine. (true, false) 5. You should instruct a patient who is starting a tetracycline prescription to stop using a calcium carbonate antacid like TUMS. (true, false) 6. Grapefruit juice should not be taken by patients who are taking a cholesterol lowering drug like Lipitor. (true, false) 7. Higher than expected blood concentrations of drugs are frequently seen in children whose dose is calculated by adjusting the adult dose by the child’s body weight. This occurs because organs of metabolism such as the liver are not fully developed. (true, false) 8. The pH of the small intestine is 1. 1.0-3.5 2. 3.5-5.7 3. 5.7-7.7 4. aboVe pH 8.0 9. The rate of intestinal blood flow is directly, inversely, n_ot, related to the rate of absorption for drugs that are passively absorbed. (Choose word to correctly complete the sentence.) 10. The toxic solvent that was used in sulfanilamide elixir in 1938 was ___?__ (give the chemical name) 11. Name the two attractive forces between the drug and water that enhance solubility in water. 1. 2. 12. Vancomycin must be administered intravenousy, orally to effectively treat a blood infection. (Choose word to correctly complete the sentence.) 13 The effectiveness of administering a drug for systemic effect via a rectal suppository is limited by two properties of the large intestine. What are they? 1. 2. 14. Match each statement with a route of absorption. A. passive transport through the cells of the GI. membrane. B. passive diffusion between the cells of the GI membrane. C. active transport through the cells of the GI. membrane. 1. Adequater described by the oil/water partition coefficient model. 2. Route of absorption for very small water soluble molecules. 3. The rate of absorption is only proportional to the concentration of drug in solution at the membrane surface at low drug concentrations. 15. Enalapril and enalaprilat are related drugs that are used to treat high blood pressure. Which drug is most suitable for intravenous administration? 16. The ideal region of the GI. tract for dissolution of a drug is the ? 17. The ideal region of the GI. tract for absorption of a drug is the _? 18. Indicate if the following groups enhance aqueous solubility (A) or lipid solubility (L) A. NH3+ B. NH2 C. N(CH3)2 D. —CH2- 19. Indicate if antibiotics (A), public health (PH). or vaccines (V) are responsible for the dramatically reduced number of deaths from the following diseases. A. Typhoid B. Scarlet Fever C. Smallpox D. Measles 20. The three requirements of an optimized drug product are safety, effectiveness, and reliability. Indicate the |aw(s) or regulation that is (are) associated with each requirement. A. Safety B. Effectiveness 0. Reliability Vlfiley Act of 1906 Second FDA Act of 1938 Kefauver-Harris Amendment of 1962 Dietary Supplement Health and Education Act of 1994 Current Good Manufacturing Practices 9‘?wa 21. Why does a rat survive perfusion of a solution of strychnine at pH 1.2 through the small intestine, but dies quickly when the pH of the perfused strychnine solution is 8.5? Strychnine is a weak base. — 22. Griseofulvin is a drug that dissolves slowly in water and is Stable in acid. You should advise a patient to take a Griseofulvin tablet ? 1. with a meal 2. 2 hours aftera meal 3. with a glass of orange juice 23. Erylhromycin-is a drug that dissolves quickly in water and degrades in acid. You should advise a patient to take an erythromycin tablet _? 1. with a meal 2. 2 hours after a meal 3. with a glass of orange juice 24. Match the properties of the drug with the indicated region of the following graph. A. Region a B. Region c C. Region d Drug has very high lipid solubility and very low aqueous solubility. Dmg is absorbed by active transport . Drug is absorbed by passive diffusion between the cells of the GI. membrane. Drug has the optimum balance of aqueous and lipid solubility. 5* PN.‘ permeability (-CH2-)n 25. Which term in the GI. absorption equation is affected by: A. the rate of intestinal blood flow B. dimensions of the drug (branched vs. compact) 1. Dm 4. C9 5 6. A Xm 26. What region of the GI. tract is associated with each statement? A. bile salts are present B. may contain 100 mL of water C. has the highest surface area D. pepsin is present E. covered by 1.0 to 1.5 mm mucus 1. mouth 2. esophagus 3. stomach 4. small intestine 5. large intestine 27. Indicate if the following drugs are more water soluble (W) or more lipid soluble (L). A. daunorubicin hydrochloride for leukemia B. griseofulvin for fungal infections C. levodopa for symptoms of Parkinsonism D. oxacillin sodium for bacterial infections E. oxazepam for treating anxiety ...
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This note was uploaded on 02/12/2010 for the course IPPH 362 taught by Professor Hem during the Spring '08 term at Purdue University-West Lafayette.

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Test 1 2007 key and test - 9-5-07 Key to Test 1 1. False...

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